期刊
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
卷 -, 期 -, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/database/bay002
关键词
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资金
- National Science Foundation
- National Institutes of Health and Department of Energy at Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank (PDB) [DBI-1338415]
- European Molecular Biology Laboratory-European Bioinformatics Institute
- Wellcome Trust [75968, 88944, 104948]
- Biotechnology and Biological Sciences Research Council [BB/G022577/1, BB/J007471/1, BB/K016970/1, BB/K020013/1, BB/M013146/1, BB/M011674/1, BB/M020347/1, BB/M020428/1]
- European Union [284209, 675858]
- Medical Research Council at PDB in Europe (PDBe) [MR/L007835/1]
- Japan Science and Technology-National Bioscience Database Center at PDB Japan (PDBj) [17933363]
- PDBj-Biological Magnetic Resonance Bank (BMRB)
- National Institute of General Medical Sciences at BMRB [GM109046]
- National Institute of General Medical Sciences at EMDataBank [GM079429]
- BBSRC [BB/K016970/1, BB/J007471/1, BB/G022577/1, BB/M020347/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G022577/1, BB/J007471/1, BB/M020347/1, BB/K016970/1] Funding Source: researchfish
- Medical Research Council [MR/L007835/1] Funding Source: researchfish
The Protein Data Bank (PDB) is the single global repository for experimentally determined 3D structures of biological macromolecules and their complexes with ligands. The worldwide PDB (wwPDB) is the international collaboration that manages the PDB archive according to the FAIR principles: Findability, Accessibility, Interoperability and Reusability. The wwPDB recently developed OneDep, a unified tool for deposition, validation and biocuration of structures of biological macromolecules. All data deposited to the PDB undergo critical review by wwPDB Biocurators. This article outlines the importance of biocuration for structural biology data deposited to the PDB and describes wwPDB biocuration processes and the role of expert Biocurators in sustaining a highquality archive. Structural data submitted to the PDB are examined for self-consistency, standardized using controlled vocabularies, cross-referenced with other biological data resources and validated for scientific/technical accuracy. We illustrate how biocuration is integral to PDB data archiving, as it facilitates accurate, consistent and comprehensive representation of biological structure data, allowing efficient and effective usage by research scientists, educators, students and the curious public worldwide.
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