期刊
CURRENT OPINION IN HIV AND AIDS
卷 13, 期 1, 页码 53-60出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/COH.0000000000000428
关键词
antimicrobial properties; antiretroviral drugs; butyrate-producing bacteria; gut microbiome; microbial dysbiosis
资金
- Mexican Government (Comision de Equidad y Genero de las Legislaturas LX-LXI)
- Mexican Government (Comision de Igualdad de Genero de la Legislatura LXII de la H. Camara de Diputados de la Republica Mexicana)
- NIH [NIDDK RO1DK112254, NIH/NIDA DP13A037979, NIH/NIAID R01AI128782]
Purpose of review Little is known on how different antiretroviral (ARV) drugs affect the gut microbiome in HIV infection; and conflicting data exists on the effect of ARV drugs on residual inflammation/immune activation and microbial translocation. Recent findings Gut microbiome involvement in the transmission and pathogenesis of HIV infection is increasingly being recognized. Various studies have shown that antiretroviral therapy (ART) is unable to restore gut health despite effective suppression of plasma HIV viremia. Indeed, the resolution of residual inflammation and gut microbial translocation is partial under ART. Very recent studies have provided new evidence that ARV combinations can differentially affect the gut microbiome, immune activation and microbial translocation. Furthermore, a recent article uncovered a link between drug metabolism and specific microbial species indicating that microbes can directly metabolically degrade ARV drugs when administered topically. Summary There are still many unanswered questions regarding ARVs and the gut microbiome. It is, therefore, critical for researchers to address the effect of distinct ARV drugs on the microbiome and vice versa: the effects of the microbiome on ARV drug metabolism, and speculate about possible therapeutic avenues.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据