期刊
CELL ADHESION & MIGRATION
卷 12, 期 4, 页码 363-377出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19336918.2018.1465156
关键词
fenestrae; livers sinusoidal endothelial cells (LSEC); STED microscopy
类别
资金
- Ministere de l'Enseignement Superieur et de la Recherche
- SIRIC BRIO, ARC, La Ligue Nationale contre le Cancer
- Equipe Labellisee, Ligue Nationale contre le Cancer 2016, SIRIC BRIO
- INCA [PLBIO15-135, PLBIO2014-182]
Discoidin domain receptors, DDR1 and DDR2, are two members of collagen receptor family that belong to tyrosine kinase receptor subgroup. Unlike other matrix receptor-like integrins, these collagen receptors have not been extensively studied. However, more and more studies are focusing on their involvement in cancer. These two receptors are present in several subcellular localizations such as intercellular junction or along type I collagen fibers. Consequently, they are involved in multiple cellular functions, for instance, cell cohesion, proliferation, adhesion, migration and invasion. Furthermore, various signaling pathways are associated with these multiple functions. In this review, we highlight and characterize hallmarks of cancer in which DDRs play crucial roles. We discuss recent data from studies that demonstrate the involvement of DDRs in tumor proliferation, cancer mutations, drug resistance, inflammation, neo-angiogenesis and metastasis. DDRs could be potential targets in cancer and we conclude this review by discussing the different ways to inhibits them.
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