期刊
CANCER DISCOVERY
卷 8, 期 4, 页码 395-402出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-17-1320
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资金
- F. Hoffmann-LaRoche AG
- AACR Project GENIE registry
- Common Fund of the Office of the Director of the NIH
- NCI
- NHGRI
- NHLBI
- NIDA
- NIMH
- NINDS
Checkpoint inhibitor therapy has been a breakthrough in cancer research, but only some patients with cancer derive substantial benefit. Although mechanisms underlying sensitivity and resistance to checkpoint inhibitors are being elucidated, the importance of organ-specific regulation of immunity is currently underappreciated. Here, we call for a greater understanding of tissue-specific immunoregulation, namely, tissue-specific immunostats, to make advances in treatments for cancer. A better understanding of how individual organs at baseline regulate the immune system could enable an improved precision medicine approach to cancer immunotherapy. (C)2018 AACR.
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