期刊
BIOMEDICAL OPTICS EXPRESS
卷 9, 期 8, 页码 -出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.9.003481
关键词
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资金
- European Research Council (ERC) [310970 MOPHIM]
- Wellcome Trust [WT101957]
- Engineering and Physical Sciences Research Council (EPSRC) [NS/A000027/1, EP/L016478/1, EP/N021177/1]
- European Union [ICT project FAMOS] [317744]
- Ramsay Memorial Trust
- EPSRC [EP/N021177/1] Funding Source: UKRI
All-optical ultrasound imaging, where ultrasound is generated and detected using light, has recently been demonstrated as a viable modality that is inherently insensitive to electromagnetic interference and exhibits wide bandwidths. High-quality 2D and 3D all-optical ultrasound images of tissues have previously been presented; however, to date, long acquisition times (ranging from minutes to hours) have hindered clinical application. Here, we present the first all-optical ultrasound imaging system capable of video-rate, real-time two-dimensional imaging of biological tissue. This was achieved using a spatially extended nano-composite optical ultrasound generator, a highly sensitive fibre-optic acoustic receiver, and eccentric illumination resulting in an acoustic source exhibiting optimal directivity. This source was scanned across a one-dimensional source aperture using a fast galvo mirror, thus enabling the dynamic synthesis of source arrays comprising spatially overlapping sources at non-unitorm source separation distances. The resulting system achieved a sustained frame rate of 15 Hz, a dynamic range of 30 dB, a penetration depth of at least 6 mm, a resolution of 75 gm (axial) by 100 gm (lateral), and enabled the dynamics of a pulsating ex vivo carotid artery to be captured. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License.
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