4.8 Article

One-Pot Photomediated Giese Reaction/Friedel-Crafts Hydroxyalkylation/Oxidative Aromatization To Access Naphthalene Derivatives from Toluenes and Enones

期刊

ACS CATALYSIS
卷 8, 期 7, 页码 6224-6229

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acscatal.8b00481

关键词

C-H activation; photocatalysis; Lewis acid catalysis; gamma-aryl ketone; naphthalene

资金

  1. National University of Singapore
  2. Ministry of Education (MOE) of Singapore [R-143-000-645-112, R-143-000-665114]
  3. GSK-EDB [R-143-000-687-592]
  4. A*STAR AME [R-143000-690-305]
  5. National Natural Science Foundation of China [21702142]

向作者/读者索取更多资源

Value-added chemicals, gamma-aryl ketones and naphthalenes, were conveniently synthesized from readily available toluenes and enones through the synergistic combination of photoredox and Lewis acid catalysis. The direct synthesis of gamma-aryl ketones represents a rare example of Giese reactions between benzylic C(sp(3))-H and enones that avoids the use of prefunctionalized metallic nucleophiles. Naphthalene derivatives were accessed through a one-pot Giese reaction/Friedel-Crafts hydroxyalkylation/oxidative aromatization sequential transformation.

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