期刊
ACS CATALYSIS
卷 8, 期 7, 页码 6738-6744出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.8b01640
关键词
alcohols; aldehydes; carboxylic acids; oxidation; electrocatalysis; electrochemistry; nitroxyl; aminoxyl
资金
- AbbVie (organic chemistry applications)
- Great Lakes Bioenergy Research Center (DOE Office of Science) [BER DE-FC02-07ER64494]
An electrocatalytic method has been developed to oxidize primary alcohols and aldehydes to the corresponding carboxylic acids using 4-acetamido-2,2,6,6-tetramethyl-piperidin-1-oxyl (ACT) as a mediator. The method successfully converts benzylic, aliphatic, heterocyclic, and other heteroatom-containing substrates to the corresponding carboxylic acids in aqueous solution at room temperature. The mild conditions enable retention of stereochemistry adjacent to the site of oxidation, as demonstrated in a 40 g-scale synthesis of a precursor to levetiracetam, a medication used to treat epilepsy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据