Palladium(II)-Catalyzed Diastereoselective 2,3-Trans C(sp(3))-H Arylation of Glycosides

We report herein the diastereoselective C(sp(3))-H arylation of glycosides. A wide range of beta- and alpha-glycosides proved able to selectively undergo Pd(II)-catalyzed coupling with diverse aryl iodides to assemble a large library of functionalized 3-arylglycosylamides. DFT calculations were performed to elucidate the unexpected trans stereoselectivity of this reaction.