期刊
NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-05297-z
关键词
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资金
- National Institutes of Health [R01 GM112048, R33 EB019785]
- National Science Foundation [CBET-1438126, IDBR-1455658]
- Shared Materials Instrumentation Facility (SMIF) at Duke University
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R33EB019785] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM112048] Funding Source: NIH RePORTER
- Div Of Chem, Bioeng, Env, & Transp Sys [1438126] Funding Source: National Science Foundation
For decades, scientists have pursued the goal of performing automated reactions in a compact fluid processor with minimal human intervention. Most advanced fluidic handling technologies (e.g., microfluidic chips and micro-well plates) lack fluid rewritability, and the associated benefits of multi-path routing and re-programmability, due to surface-adsorption-induced contamination on contacting structures. This limits their processing speed and the complexity of reaction test matrices. We present a contactless droplet transport and processing technique called digital acoustofluidics which dynamically manipulates droplets with volumes from 1 nL to 100 mu L along any planar axis via acoustic-streaming-induced hydrodynamic traps, all in a contamination-free ( lower than 10(-10)% diffusion into the fluorinated carrier oil layer) and biocompatible (99.2% cell viability) manner. Hence, digital acoustofluidics can execute reactions on overlapping, non-contaminated, fluidic paths and can scale to perform massive interaction matrices within a single device.
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