期刊
NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-03903-8
关键词
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资金
- Key Research Program of Frontier Sciences, CAS [QYZDB-SSW-SMC013]
- National Key R&D Program of China [2017YFA0205501]
- National Natural Science Foundation of China [31530026, 81671810]
- Strategic Priority Research Program, CAS [XDA09030306, XDPB0304]
- Foundation of the Thousand Talents Plan for Young Professionals and Jiangsu Specially-Appointed Professor
- Yangzhou University
- Young Elite Scientist Sponsorship Program by CAST [2015QNRC001]
- China Postdoctoral Science Foundation [2015M570158]
- China Postdoctoral Science Special Foundation [2016T90143]
Nanomaterials with intrinsic enzyme-like activities (nanozymes), have been widely used as artificial enzymes in biomedicine. However, how to control their in vivo performance in a target cell is still challenging. Here we report a strategy to coordinate nanozymes to target tumor cells and selectively perform their activity to destruct tumors. We develop a nanozyme using nitrogen-doped porous carbon nanospheres which possess four enzyme-like activities (oxidase, peroxidase, catalase and superoxide dismutase) responsible for reactive oxygen species regulation. We then introduce ferritin to guide nitrogen-doped porous carbon nanospheres into lysosomes and boost reactive oxygen species generation in a tumor-specific manner, resulting in significant tumor regression in human tumor xenograft mice models. Together, our study provides evidence that nitrogen-doped porous carbon nanospheres are powerful nanozymes capable of regulating intracellular reactive oxygen species, and ferritinylation is a promising strategy to render nanozymes to target tumor cells for in vivo tumor catalytic therapy.
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