4.8 Article

A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA

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NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -

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NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-04704-9

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  1. National Institutes of Health (NIH) [U19 AI117905]
  2. NIH [NIH HHSN272201400024C]
  3. NCI Cancer Center Support Grant [P30 CA068485]
  4. CTSA award from the National Center for Advancing Translational Sciences [UL1 TR000445]
  5. NATIONAL CANCER INSTITUTE [P30CA068485] Funding Source: NIH RePORTER
  6. NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000445] Funding Source: NIH RePORTER
  7. NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U19AI117905] Funding Source: NIH RePORTER

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The high rate of antigenic drift in seasonal influenza viruses necessitates frequent changes in vaccine composition. Recent seasonal H3 vaccines do not protect against swine-origin H3N2 variant (H3N2v) strains that recently have caused severe human infections. Here, we report a human V(H)1-69 gene-encoded monoclonal antibody (mAb) designated H3v-47 that exhibits potent cross-reactive neutralization activity against human and swine H3N2 viruses that circulated since 1989. The crystal structure and electron microscopy reconstruction of H3v-47 Fab with the H3N2v hemagglutinin (HA) identify a unique epitope spanning the vestigial esterase and receptor-binding subdomains that is distinct from that of any known neutralizing antibody for influenza A H3 viruses. MAb H3v-47 functions largely by blocking viral egress from infected cells. Interestingly, H3v-47 also engages Fc gamma receptor and mediates antibody dependent cellular cytotoxicity (ADCC). This newly identified conserved epitope can be used in design of novel immunogens for development of broadly protective H3 vaccines.

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