期刊
NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-05193-6
关键词
-
资金
- Fonds der Chemischen Industrie
- University of Munster
Site selective chemical functionalization at unactivated C(sp(3))-H bonds is highly challenging and recent successful studies mostly focus on the use of transition metal catalysis in combination with directing groups. Radical chemistry offers a complementary approach with the Barton and the Hofmann-Loffler-Freytag reactions being landmark contributions in the area of remote C-H functionalization at unactivated aliphatic sites. Herein we introduce the concept of radical translocation arylation at unactivated secondary and tertiary C(sp(3))-H bonds in various alcohols. The straightforward two-step sequence comprises an ionic alcohol sulfo-nylation with especially designed ortho-iodoaryl sulfonyl chlorides followed by a radical cascade reaction including aryl radical generation, remote radical translocation, aryl migration, reduction, and SO2 extrusion to give the corresponding.-arylated alcohols. Moderate to good yields are obtained, remote C-H arylation occurs with excellent regioselectivity and for secondary C(sp(3))-H bonds good to excellent stereoselectivity is achieved.
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