期刊
JOURNAL OF ABNORMAL PSYCHOLOGY
卷 121, 期 3, 页码 649-658出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0026371
关键词
psychopathy; paralimbic cortex dysfunction; limbic structure dysfunction; voxel-based morphometry (VBM); MRI
资金
- NIDA NIH HHS [1-R01-DA026505, R01 DA026505, R01 DA020870, 1-R01-DA020870-01] Funding Source: Medline
- NIMH NIH HHS [F32 MH086247, R01 MH070539, 1F32 MH086247, 1-R01-MH070539] Funding Source: Medline
Psychopaths impose large costs on society, as they are frequently habitual, violent criminals. The pervasive nature of emotional and behavioral symptoms in psychopathy suggests that several associated brain regions may contribute to the disorder. Studies employing a variety of methods have converged on a set of brain regions in paralimbic cortex and limbic areas that appear to be dysfunctional in psychopathy. The present study further tests this hypothesis by investigating structural abnormalities using voxel-based morphometry in a sample of incarcerated men (N = 296). Psychopathy was associated with decreased regional gray matter in several paralimbic and limbic areas, including bilateral parahippocampal, amygdala, and hippocampal regions, bilateral temporal pole, posterior cingulate cortex, and orbitofrontal cortex. The consistent identification of paralimbic cortex and limbic structures in psychopathy across diverse methodologies strengthens the interpretation that these regions are crucial for understanding neural dysfunction in psychopathy.
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