Five new polyketides from the basidiomycete Craterellus odoratus

Five new polyketides, craterellones A-E (1-5), were isolated from cultures of basidiomycete Craterellus odoratus, together with five known compounds (6-10). Structures of 1-5 were elucidated on the basis of extensive spectroscopic analysis. All compounds were evaluated for their inhibitory activities against one isozyme of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1) and cytotoxic activities on five tumor cell lines. Compound 10 exhibited significant cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480, with IC50 values of 0.50, 0.69, 0.64, 1.10, 0.54 mu M, respectively.