期刊
NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-05113-8
关键词
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资金
- National Key R&D Program of China [2017YFA0207303, 2016YFC1303100]
- National Science Fund for Distinguished Young Scholars [21725502]
- Key Basic Research Program of Science and Technology Commission of Shanghai Municipality [17JC1400100]
- National Natural Sciences Foundation of China [81402154]
- Shanghai Municipal Commission of Health and Family Planning [20144Y0097]
- Shanghai Commission of Science and Technology Planning [14411969400]
Local recurrence is a common cause of treatment failure for patients with solid tumors. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and, thereby improve prognosis. Here, we report in vivo assembly of the second near-infrared window (NIR-II) emitting downconversion nanoparticles (DCNPs) modified with DNA and targeting peptides to improve the image-guided surgery for metastatic ovarian cancer. The NIR-II imaging quality with DCNPs is superior to that of clinically approved ICG with good photostability and deep tissue penetration (8 mm). Stable tumor retention period experienced 6 h by in vivo assembly of nanoprobes can be used for precise tumor resection. Superior tumor-to-normal tissue ratio is successfully achieved to facilitate the abdominal ovarian metastases surgical delineation. Metastases with <= 1 mm can be completely excised under NIR-II bioimaging guidance. This novel technology provides a general new basis for the future design of nanomaterials for medical applications.
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