期刊
NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-03109-y
关键词
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资金
- Medical Research Council [MC_UU_12013/3, MC_UU_12013/1, G0902313, MR/L020149/1]
- CRUK Integrative Cancer Epidemiology Programme [C18281/A19169]
- UK Medical Research Council [MR/L003120/1]
- British Heart Foundation [RG/13/13/30194]
- NIHR Cambridge Biomedical Research Centre
- BHF Cambridge Centre of Excellence [RE/13/6/30180]
- Wellcome Trust [105602/Z/14/Z, 090532, 098381, 106130, 102215/2/13/2]
- Li Ka Shing Foundation
- NIHR Oxford Biomedical Research Centre
- European Research Council [ERC-2015-CoG-681742-NASCENT]
- Swedish Research Council (Distinguished Young Researcher Award in Medicine)
- NIHR
- Wellcome Trust Investigator Award [WT 202849/Z/16/Z]
- Medical Research Council Clinical Research Training Fellowship [MR/P00167X/1]
- NIH [R01DK098032, U01DK105535]
- National Institute for Health Research (NIHR) Oxford BRC
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [U01DK105535] Funding Source: NIH RePORTER
- British Heart Foundation [RG/16/4/32218] Funding Source: researchfish
- Cancer Research UK [19169] Funding Source: researchfish
- Medical Research Council [HDR-5006, MR/N011317/1, MC_EX_MR/M01424X/1, G9815508, HDR-1004, MR/P013880/1, G0600705, MR/P00167X/1, MC_U123292700, MR/L003120/1, MC_UU_12013/4, MR/P02811X/1, MC_PC_15018, MR/L010305/1, MC_PC_MR/R020183/1, MC_UU_00026/3, MC_UU_12012/1, MC_UU_12012/5] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0617-10113, NF-SI-0611-10099, NF-SI-0512-10165, NF-SI-0513-10109] Funding Source: researchfish
- Novo Nordisk Fonden [NNF17OC0026828] Funding Source: researchfish
- MRC [MR/P02811X/1, MC_U123292700, MC_UU_12012/1, MC_UU_12013/4, MR/L003120/1, MC_PC_MR/R020183/1, G0902313, MC_UU_12012/5, MR/P00167X/1, MC_EX_MR/M01424X/1, MR/P013880/1, MR/N011317/1, MC_UU_00026/3, G0600705, MC_UU_12013/3, MR/L020149/1, MC_UU_12013/1] Funding Source: UKRI
Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks that allow causal inference. Here, we discuss the characteristics of Recall-by-Genotype (RbG) as a study design aimed at addressing both these needs. We describe two broad scenarios for the application of RbG: studies using single variants and those using multiple variants. We consider the efficacy and practicality of the RbG approach, provide a catalogue of UK-based resources for such studies and present an online RbG study planner.
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