Antibacterial resin monomers based on quaternary ammonium and their benefits in restorative dentistry

Antibacterial resin monomers are unique molecules that provide dental resins with bio-active function'', i.e. the ability to control bacterial infection. They have strong antibacterial activity when unpolymerized and also demonstrate contact inhibitory effects after being polymerized without releasing antibacterial components. Intensive research has been conducted on antibacterial monomers based on quaternary ammonium, such as methacryloyloxydodecylpyridinium bromide ( MDPB), focusing on their basic properties and uses in several resinous restoratives. As represented by successful commercialization of an adhesive system incorporating MDPB, quaternary ammonium based antibacterial monomers have the potential for utilization in various restorative materials and regimens, including caries management and pulp care. (C) 2012 Japanese Association for Dental Science. Published by Elsevier Ltd. All rights reserved.