期刊
NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-017-02598-7
关键词
-
资金
- National Science Foundation of China [81373366]
- National Science Foundation of Shanghai, China [15ZR1432500]
- Shanghai Committee of Science and Technology, China [12XD1403800]
- Funds for Interdisciplinary Projects of Medicine and Engineering of Shanghai JiaoTong University [YG2015MS06, YG2017MS22, YG2016QN22]
- National Science and Technology Major Projects for Major New Drugs Innovation and Development [2017ZX09101005-008-002]
- SUMHS seed foundation project [HMSF-16-21-010]
- Science and Technology Development Foundation of Pudong New District, Shanghai, China [PKJ2016-Y55]
As a conductive nanomaterial, graphene has huge potentials in nerve function restoration by promoting electrical signal transduction and metabolic activities with unique topological properties. Polydopamine (PDA) and arginylglycylaspartic acid (RGD) can improve cell adhesion in tissue engineering. Here we report an integrated 3D printing and layer-by-layer casting (LBLC) method in multi-layered porous scaffold fabrication. The scaffold is composed of single-layered graphene (SG) or multi-layered graphene (MG) and polycaprolactone (PCL). The electrically conductive 3D graphene scaffold can significantly improve neural expression both in vitro and in vivo. It promotes successful axonal regrowth and remyeli-nation after peripheral nerve injury. These findings implicate that graphene-based nano-technology have great potentials in peripheral nerve restoration in preclinical and clinical application.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据