期刊
NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-018-03205-z
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资金
- Newton Trust UK-China NSFC initiative [MR/P007597/1, 81661138006]
- BBSRC GCRF scheme
- EPSRC [EP/F500351/1]
- Wellcome Trust on a Genomic Medicine and Statistics DPhil grant
- European Union: European regional development fund (ERDF)
- Conseil Regional de La Reunion
- Centre de Cooperation internationale en Recherche agronomique pour le Developpement (CIRAD)
- National Natural Science Foundation of China [81625014]
- Dorothy Hodgkin Fellowship - Royal Society [DH140195]
- Sir Henry Dale Fellowship - Wellcome Trust [109385/Z/15/Z]
- Sir Henry Dale Fellowship - Royal Society [109385/Z/15/Z]
- Wellcome Trust [102541/A/13/Z]
- Royal Society [102541/A/13/Z]
- Sir Henry Dale Fellowship
- MRC [MR/P007597/1] Funding Source: UKRI
- Medical Research Council [MR/P007597/1] Funding Source: researchfish
Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of the colistin resistance gene mcr-1 poses a significant public health threat, requiring global monitoring and surveillance. Here, we characterize the global distribution of mcr-1 using a data set of 457 mcr-1-positive sequenced isolates. We find mcr-1 in various plasmid types but identify an immediate background common to all mcr-1 sequences. Our analyses establish that all mcr-1 elements in circulation descend from the same initial mobilization of mcr-1 by an ISApl1 transposon in the mid 2000s (2002-2008; 95% highest posterior density), followed by a marked demographic expansion, which led to its current global distribution. Our results provide the first systematic phylogenetic analysis of the origin and spread of mcr-1, and emphasize the importance of understanding the movement of antibiotic resistance genes across multiple levels of genomic organization.
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