期刊
NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-04488-y
关键词
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资金
- Technische Universitat Munchen-Institute for Advanced Study - German Excellence Initiative
- European Union Seventh Framework Programme [291763]
- Deutsche Forschungsgemeinschaft within the SFB [863]
- European Union's Horizon Research and Innovation program for the Marie Sklodowska Curie Fellowship [747007]
- Deutsche Forschungsgemeinschaft the International Research Training Group ATUMS [IRTG 2022]
- Marie Curie Actions (MSCA) [747007] Funding Source: Marie Curie Actions (MSCA)
Life is a dissipative nonequilibrium structure that requires constant consumption of energy to sustain itself. How such an unstable state could have selected from an abiotic pool of molecules remains a mystery. Here we show that liquid phase-separation offers a mechanism for the selection of dissipative products from a library of reacting molecules. We bring a set of primitive carboxylic acids out-of-equilibrium by addition of high-energy condensing agents. The resulting anhydrides are transiently present before deactivation via hydrolysis. We find the anhydrides that phase-separate into droplets to protect themselves from hydrolysis and to be more persistent than non-assembling ones. Thus, after several starvation-refueling cycles, the library self-selects the phase-separating anhydrides. We observe that the selfselection mechanism is more effective when the library is brought out-of-equilibrium by periodic addition of batches as opposed to feeding it continuously. Our results suggest that phase-separation offers a selection mechanism for energy dissipating assemblies.
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