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Marcel Kool et al.
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Laura Di Magno et al.
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Miriam J. Smith et al.
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Patched-1 Proapoptotic Activity Is Downregulated by Modification of K1413 by the E3 Ubiquitin-Protein Ligase Itchy Homolog
Xiaole L. Chen et al.
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Fritz Aberger et al.
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Yin-Yang strands of PCAF/Hedgehog axis in cancer control
Paola Infante et al.
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Amy L. Cherry et al.
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Joanna Triscott et al.
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D. Mazza et al.
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James Briscoe et al.
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Two cases of nevoid basal cell carcinoma syndrome associated with meningioma caused by a PTCH1 or SUFU germline mutation
Chihiro Kijima et al.
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Bill R. Miller et al.
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High Frequency of Germline SUFU Mutations in Children With Desmoplastic/Nodular Medulloblastoma Younger Than 3 Years of Age
Laurence Brugieres et al.
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Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma
Ingrid Slade et al.
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Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3β Regulates Its Stability and Localization in the Primary Cilium
Yan Chen et al.
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Itraconazole Side Chain Analogues: Structure-Activity Relationship Studies for Inhibition of Endothelial Cell Proliferation, Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Glycosylation, and Hedgehog Signaling
Wei Shi et al.
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Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
Woong Kim et al.
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Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal
L. Di Marcotullio et al.
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Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets
Christopher Hooper et al.
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Chengbing Wang et al.
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Eric W. Humke et al.
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Arresting a Transient Receptor Potential (TRP) Channel β-ARRESTIN 1 MEDIATES UBIQUITINATION AND FUNCTIONAL DOWN-REGULATION OF TRPV4
Arun K. Shukla et al.
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Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line SUFU mutations
Laurence Brugieres et al.
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Identification of a SUFU Germline Mutation in a Family With Gorlin Syndrome
L. Pastorino et al.
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Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways
Jeffrey J. Kovacs et al.
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Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins
Thomas Mund et al.
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Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
Miao-Hsueh Chen et al.
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Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin-proteasome pathway
S. Yue et al.
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The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein
Xudong Zhao et al.
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β-arrestin-mediated localization of smoothened to the primary cilium
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Deepali Bhandari et al.
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Lucia Di Marcotullio et al.
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Jin Jiang
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Neehar Bhatia et al.
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Qing Zhang et al.
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Y Pan et al.
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Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change
E Gallagher et al.
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J Svärd et al.
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EG Huntzicker et al.
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BW Wang et al.
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AF Cooper et al.
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Cilia and Hedgehog responsiveness in the mouse
D Huangfu et al.
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Ubiquitin and ubiquitin-like proteins as multifunctional signals
RL Welchman et al.
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Retrospective family study of childhood medulloblastoma
D Ng et al.
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Activity-dependent internalization of smoothened mediated by β-arrestin 2 and GRK2
W Chen et al.
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Mammalian numb proteins promote notch1 receptor ubiquitination and degradation of the notch1 intracellular domain
MA McGill et al.
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MD Taylor et al.
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AR Altaba et al.
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PW Ingham et al.
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Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
L Deng et al.
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