期刊
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
卷 42, 期 8, 页码 1592-1605出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-011-1399-2
关键词
Autism; Evidence base; Pharmacology; Review; Trials
This paper presents a systematic review, rating and synthesis of the empirical evidence for the use of psychotropic medications in children with autism spectrum disorders (ASD). Thirty-three randomized controlled trials (RCTs) published in peer-reviewed journals qualified for inclusion and were coded and analyzed using a systematic evaluative method specific to autism research (Reichow et al. in Journal of Autism and Developmental Disorders 38:1311-1319, 2008). Results are presented by agent and primary target symptom(s). The findings suggest established evidence for relatively few agents, with preliminary and promising evidence for a larger group. Challenges and opportunities in the developing field of ASD psychopharmacology are identified, and recommendations for further research are provided.
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