期刊
CANCER MICROENVIRONMENT
卷 5, 期 2, 页码 133-149出版社
SPRINGER
DOI: 10.1007/s12307-011-0091-6
关键词
Tumor-associated myeloid cells (TAMCs); Polarized inflammation; Tumor-associated macrophages (TAMs); Myeloid-derived suppressor cells (MDSCs); Angiogenic monocytes Tie2+ (TEMs); Tumor-associated neutrophils (TANs)
类别
资金
- Associazione Italiana Ricerca sul Cancro (AIRC), Italy
- Fondazione Cariplo, Italy
- Ministero Universita Ricerca (MUR), Italy
- Ministero della Salute
- Regione Piemonte [331]
The construction of an inflammatory microenvironment provides the fuel for cancer development and progression. Hence, solid tumors promote the expansion and the recruitment of leukocyte populations, among which tumor-associated myeloid cells (TAMCs) represent a paradigm for cancer-promoting inflammation. TAMCs group heterogeneous phagocytic populations stemming from a common myeloid progenitor (CMP), that orchestrate various aspects of cancer, including: diversion and skewing of adaptive responses; immunosuppression; cell growth; angiogenesis; matrix deposition and remodelling; construction of a metastatic niche and actual metastasis. Several evidence indicate that TAMCs show plasticity and/or functional heterogeneity, suggesting that tumour-derived factors promote their functional reprogramming towards protumoral activities. While recent studies have attempted to address the role of microenvironment signals, the interplay between cancer cells, innate and adaptive immunity is now emerging as a crucial step of the TAMCs reprogramming. Here we discuss the evidence for the differentiation of TAMCs during the course of tumor progression and the molecular mechanisms that regulate such event.
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