相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment
Ying-Chao Duan et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Stepwise assembly of functional C-terminal REST/NRSF transcriptional repressor complexes as a drug target
Ken Inui et al.
PROTEIN SCIENCE (2017)
The drug-target residence time model: a 10-year retrospective
Robert A. Copeland
NATURE REVIEWS DRUG DISCOVERY (2016)
A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 inhibitors in SCLC
Helai P. Mohammad et al.
CANCER CELL (2015)
Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting
Toshimasa Itoh et al.
NUCLEIC ACIDS RESEARCH (2015)
The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors
Daniel Zingg et al.
NATURE COMMUNICATIONS (2015)
A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1
Polina Prusevich et al.
ACS CHEMICAL BIOLOGY (2014)
Episensitization: Therapeutic Tumor Resensitization by Epigenetic Agents: A Review and Reassessment
Bryan Oronsky et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2014)
Chromatin Repressive Complexes in Stem Cells, Development, and Cancer
Anne Laugesen et al.
CELL STEM CELL (2014)
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
Katrina J. Falkenberg et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Long Non-Coding RNA BANCR Promotes Proliferation in Malignant Melanoma by Regulating MAPK Pathway Activation
Ruiya Li et al.
PLOS ONE (2014)
Poised epigenetic states and acquired drug resistance in cancer
Robert Brown et al.
NATURE REVIEWS CANCER (2014)
Cyclin-Dependent Kinase Inhibitor Dinaciclib Interacts with the Acetyl-Lysine Recognition Site of Bromodomains
Mathew P. Martin et al.
ACS CHEMICAL BIOLOGY (2013)
Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1 (DNA methyltransferase 1)-independent manner
Lihua Jin et al.
BIOCHEMICAL JOURNAL (2013)
Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells
Shauna N. Vasilatos et al.
CARCINOGENESIS (2013)
Selective Inhibition of p300 HAT Blocks Cell Cycle Progression, Induces Cellular Senescence, and Inhibits the DNA Damage Response in Melanoma Cells
Gai Yan et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition
Cory M. Johannessen et al.
NATURE (2013)
Cancer Epigenetics: From Mechanism to Therapy
Mark A. Dawson et al.
CELL (2012)
Structure of HDAC3 bound to co-repressor and inositol tetraphosphate
Peter J. Watson et al.
NATURE (2012)
Combinatorial drug therapy for cancer in the post-genomic era
Bissan Al-Lazikani et al.
NATURE BIOTECHNOLOGY (2012)
Epigenetic protein families: a new frontier for drug discovery
Cheryl H. Arrowsmith et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Impact of enzyme concentration and residence time on apparent activity recovery in jump dilution analysis
Robert A. Copeland et al.
ANALYTICAL BIOCHEMISTRY (2011)
Antitumor Activity of YM155, a Selective Small-Molecule Survivin Suppressant, Alone and in Combination with Docetaxel in Human Malignant Melanoma Models
Kentaro Yamanaka et al.
CLINICAL CANCER RESEARCH (2011)
Directed Evolution of Sortase A Mutants with Altered Substrate Selectivity Profiles
Kirill Piotukh et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases
Po-Hsien Huang et al.
MOLECULAR PHARMACOLOGY (2011)
Structurally Designed trans-2-Phenylcyclopropylamine Derivatives Potently Inhibit Histone Demethylase LSDI/KDM1
Shinya Mimasu et al.
BIOCHEMISTRY (2010)
Comparative Analysis of Small Molecules and Histone Substrate Analogues as LSD1 Lysine Demethylase Inhibitors
Jeffrey C. Culhane et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2
Claudia Binda et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Chemical phylogenetics of histone deacetylases
James E. Bradner et al.
NATURE CHEMICAL BIOLOGY (2010)
Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site
Jenny Bostrom et al.
SCIENCE (2009)
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
Beth Apsel et al.
NATURE CHEMICAL BIOLOGY (2008)
LSD1 and the chemistry of histone demethylation
Jeffrey C. Culhane et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2007)
Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group
Thomas Beckers et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
Mechanistic analysis of a suicide inactivator of histone demethylase LSD1
Lawrence M. Szewczuk et al.
BIOCHEMISTRY (2007)
Bisubstrate inhibition:: Theory and application to N-acetyltransferases
Michael Yu et al.
BIOCHEMISTRY (2006)
The NCI60 human tumour cell line anticancer drug screen
Robert H. Shoemaker
NATURE REVIEWS CANCER (2006)
Human histone demethylase LSD1 reads the histone code
F Forneris et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
RA Irizarry et al.
BIOSTATISTICS (2003)
A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
BM Bolstad et al.
BIOINFORMATICS (2003)