期刊
ONCOLOGY LETTERS
卷 16, 期 3, 页码 2887-2892出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2018.9041
关键词
nasopharyngeal carcinoma; Epstein-Barr virus; microRNA; BART7; natural killer cells
类别
资金
- Health and Medical Research Fund from Food and Health Bureau, Hong Kong SAR [01121626]
- University of Hong Kong
- S. K. Yee Medical Foundation Grant
Evasion from natural killer (NK) cell surveillance enables cancer to proliferate and spread at the early stages. NK cells mediate specific cytolysis by activation of the triggering receptors on their cell surface, of which the communication between natural killer group 2, member D (NKG2D) and major histocompatibility complex class I chain-related peptide A (MICA) is a key regulatory axis. It has been indicated that cancer cells can reduce the surface expression of MICA, which thereby reduces the cytotoxicity of NK cells. In nasopharyngeal carcinoma (NPC), however, the underlying mechanism remains unclear. The present study indicated that MICA expression in NPC was regulated by TGF1. Furthermore, the human MICA gene was demonstrated to contain the c-Myc binding site in the promoter region. Notably, the results suggested that TGF1 upregulated MICA expression by promoting c-Myc expression. Additionally, the findings demosntrated that TGF1 expression in NPC was negatively controlled by Epstein-Barr virus-encoded microRNA BART7 (ebv-miR-BART7). In ebv-miR-BART7-expressing NPC, the TGF1/c-Myc/MICA regulatory axis was significantly inhibited. Notably, functional analysis indicated that NPC cells expressing ebv-miR-BART7 were less sensitive to the cytolysis mediated by NK cells. In conclusion, the present results revealed that ebv-miR-BART7-expressing NPC may impair NK cells recognition and activity, which suggests that targeting ebv-miR-BART7 may be a useful therapeutic strategy in NPC immunotherapy.
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