期刊
PHARMACOLOGICAL REVIEWS
卷 64, 期 3, 页码 645-675出版社
AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
DOI: 10.1124/pr.111.004762
关键词
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资金
- National Science Foundation [0347259]
- National Institutes of Health National Center for Research Resources [P20-RR016471]
- National Heart, Lung and Blood Institute [R01-HL098279]
- American Heart Association, Great Rivers Affiliate
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [0347259] Funding Source: National Science Foundation
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0851869] Funding Source: National Science Foundation
The importance of adult neurogenesis has only recently been accepted, resulting in a completely new field of investigation within stem cell biology. The regulation and functional significance of adult neurogenesis is currently an area of highly active research. G-protein-coupled receptors (GPCRs) have emerged as potential modulators of adult neurogenesis. GPCRs represent a class of proteins with significant clinical importance, because approximately 30% of all modern therapeutic treatments target these receptors. GPCRs bind to a large class of neurotransmitters and neuromodulators such as norepinephrine, dopamine, and serotonin. Besides their typical role in cellular communication, GPCRs are expressed on adult neural stem cells and their progenitors that relay specific signals to regulate the neurogenic process. This review summarizes the field of adult neurogenesis and its methods and specifies the roles of various GPCRs and their signal transduction pathways that are involved in the regulation of adult neural stem cells and their progenitors. Current evidence supporting adult neurogenesis as a model for self-repair in neuropathologic conditions, adult neural stem cell therapeutic strategies, and potential avenues for GPCR-based therapeutics are also discussed.
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