期刊
ONCOLOGY LETTERS
卷 15, 期 4, 页码 4627-4634出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2018.7902
关键词
receptor for advanced glycation end-products; cancer malignancy; papaverine; fibrosarcoma cells
类别
资金
- Government of Egypt
- Japan Society for the Promotion of Science [26450152]
- Grants-in-Aid for Scientific Research [26450152, 15K10435, 16K08327] Funding Source: KAKEN
Receptor for advanced glycation end-products ( RAGE) is a pattern recognition receptor implicated in the pathogenesis of certain types of cancer. In the present study, papaverine was identified as a RAGE inhibitor using the conversion to small molecules through optimized-peptide strategy drug design system. Papaverine significantly inhibited RAGE-dependent nuclear factor kappa-B activation driven by high mobility group box-1, a RAGE ligand. Using RAGE- or dominant-negative RAGE-expressing HT1080 human fibrosarcoma cells, the present study revealed that papaverine suppressed RAGE-dependent cell proliferation and migration dose-dependently. Furthermore, papaverine significantly inhibited cell invasion. The results of the present study suggested that papaverine could inhibit RAGE, and provided novel insights into the field of RAGE biology, particularly anticancer therapies.
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