期刊
EPIGENOMICS
卷 10, 期 5, 页码 519-524出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2017-0159
关键词
DNA methylation; LINE-1; parvalbumin; postmortem brain; schizophrenia
资金
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- FAPESP [2017/00624-5]
- Sunovion
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [17/00624-5] Funding Source: FAPESP
Deficits of brain parvalbumin (PV) are a consistent finding in schizophrenia and models of psychosis. We investigated whether this is associated with abnormal PV gene (PVALB) methylation in the brain in schizophrenia. Bisulfite pyrosequencing was used to determine cytosine (CpG) methylation in a PVALB promoter sequence. Greater PVALB methylation was found in schizophrenia hippocampus, while no differences were observed in prefrontal cortex. LINE-1 methylation, a measure of global methylation, was also elevated in both regions in schizophrenia, although the PVALB change was independent of this effect. These results provide the first evidence that PVALB promoter methylation is abnormal in schizophrenia and suggest that this epigenetic finding may relate to the reduction of PV expression seen in the disease.
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