期刊
EPIGENOMICS
卷 10, 期 5, 页码 597-612出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2017-0087
关键词
important economic trait; methylome; transcriptome
资金
- National Natural Science Foundation of China (NSFC) [31472076, 31402046]
- National Basic Research Program of China (973 Program) [2013CB835205]
- Science Fund for Distinguished Young Scholars of Hubei Province of China [2014CFA024]
- Research Project of Chinese Ministry of Education [113048A]
- Fundamental Research Funds for the Central Universities [2662017PY030]
Aim: Integrated analysis of methylome and transcriptome may help understand the molecular basis of the different breeds with different traits of commercial interest. Materials & methods: We obtained the first genome-wide methylome with single-base resolution, miRNAome and transcriptome from three swine breeds. Results: We displayed the landscape of the three omics in the whole-genome level. Integrated outcomes of methylome with genetic selection, miRNAome and transcriptome are also provided. Finally, we identified 11 candidate differentially methylated genes associated with phenotype variance in pigs. Conclusion: DNA methylation not only suppresses transcriptome but also miRNAome. The different - omics data have complicated interaction in directly or indirectly and exhibited close relations with the distinct phenotypic traits of growth, disease resistance and energy metabolism.
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