期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 9, 期 7, 页码 702-707出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.8b00161
关键词
Antibiotic resistance; antibiotics; biofilms; antibiotic repotentiation; antibiotic adjuvants
资金
- National Institutes of Health [GM055769]
In the last 30 years, development of new classes of antibiotics has slowed, increasing the necessity for new options to treat multidrug resistant bacterial infections. Development of antibiotic adjuvants that increase the effectiveness of currently available antibiotics is a promising alternative approach to classical antibiotic development. Reports of the ability of the natural product meridianin D to modulate bacterial behavior have been rare. Herein, we describe the ability of meridianin D to inhibit biofilm formation of methicillin-resistant Staphylococcus aureus (MRSA) and to increase the potency of colistin against colistin-resistant and sensitive Gram-negative bacteria. Analogues were identified that are capable of inhibiting and dispersing MRSA biofilms and lowering the colistin MIC to below the CLSI breakpoint against Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli.
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