期刊
CELL DEATH & DISEASE
卷 9, 期 -, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/s41419-018-0725-4
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类别
资金
- National Natural Science Foundation of China [31771276, 31471095]
- Chinese Postdoctoral Science Foundation [2016M591557]
- Postdoctoral Foundation of Heilongjiang Province [LBH-Z16241]
- Novel Foundation of Heilongjiang Province of China [YJSCX2015-13HYD]
Many long noncoding RNAs (lncRNAs) have been identified as powerful regulators of lung adenocarcinoma (LAD). However, the role of HOXA-AS3, a novel lncRNA, in LAD is largely unknown. In this study, we showed that HOXA-AS3 was significantly upregulated in LAD tissues and A549 cells. After knockdown of HOXA-AS3, cell proliferation, migration, and invasion were inhibited. Xenografts derived from A549 cells transfected with shRNA/ HOXA-AS3 had significantly lower tumor weights and smaller tumor volumes. We also demonstrated that HOXA-AS3 increased HOXA6 mRNA stability by forming an RNA duplex. In addition, HOXA6 promoted cell proliferation, migration, and invasion in vitro. Using a RNA pull-down assay, we found that HOXA-AS3 bonded with NF110, which regulated the cell localization of HOXA-AS3. Moreover, histone acetylation was involved in upregulation of HOXA-AS3. These results demonstrate that HOXA-AS3 was activated in LAD and supported cancer cell progression. Therefore, inhibition of HOXA-AS3 could be an effective targeted therapy for patients with LAD.
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