期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 18, 页码 9469-9478出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b02737
关键词
iron oxide; PEDOT; near-infrared; antibacterial activity; recyclable; photothermal
资金
- Ministry of Trade, Industry and Energy (MOTIE) [10046506, 10048377]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2014055946]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10046506, 10048377] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Growing microbial resistance that renders antibiotic treatment vulnerable has emerged, attracting a great deal of interest in the need to develop alternative antimicrobial treatments. To contribute to this effort, we report magnetic iron oxide (Fe3O4) nanoparticles (NPs) coated with catechol-conjugated poly(vinylpyrrolidone) sulfobetaines (C-PVPS). This negatively charged Fe3O4@C-PVPS is subsequently encapsulated by poly(3,4-ethylenedioxythiophene) (PEDOT) following a layer-by-layer (LBL) self-assembly method. The obtained Fe3O4@C-PVPS:PEDOT nanoparticles appear to be novel NIR-irradiated photothermal agents that can achieve effective bacterial killing and are reusable after isolation of the used particles using external magnetic fields. The recyclable Fe3O4@C-PVPS:PEDOT NPs exhibit a high efficiency in converting photothermal heat for rapid antibacterial effects against Staphylococcus aureus and Escherichia coli. In this study, antibacterial tests for repeated uses maintained almost 100% antibacterial efficiency during three cycles and provided rapid and effective killing of 99% Gram-positive and -negative bacteria within 5 min of near-infrared (NIR) light exposure. The core-shell nanoparticles (Fe3O4@C-PVPS:PEDOT) exhibit the required stability, and their paramagnetic nature means that they rapidly convert photothermal heat sufficient for use as NIR-irradiated antibacterial photothermal sterilizing agents.
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