期刊
JOURNAL OF FUNCTIONAL FOODS
卷 48, 期 -, 页码 153-158出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2018.07.009
关键词
Immune function; NK cell activity; Probiotics; Weissella ciboria JW15
资金
- Cooperative Research Program for Agriculture Science & Technology Development [PJ010835]
The aim of this study was to investigate the impact of consuming Weissella cibaria (W. cibaria) JW15 on natural killer (NK) cell activity, cytokines and immunoglobulins (Igs). This randomized, double-blinded, placebo-controlled study enrolled 100 nondiabetic participants. For eight weeks, the probiotic group consumed capsules containing 1 x 10(10) colony forming units (cfu) of W cibaria JW15 daily, whereas the placebo group consumed the same capsules without a probiotic. NK cell activity at effector cell (E; peripheral blood mononuclear cells, PBMCs):target cell (T; K562 cells) ratios of 10:1, 5:1, 2.5:1, or 1.25:1 was significantly increased in the probiotic group compared to the placebo group at 8 weeks after baseline. The probiotic group had significantly greater increases in NK cell activity than the placebo group under all assay conditions. Daily consumption of the W. ciboria JW15 probiotic effectively enhanced immune functions by increasing NK cell activity.
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