期刊
JOURNAL OF FUNCTIONAL FOODS
卷 48, 期 -, 页码 106-116出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2018.06.025
关键词
Naringenin; Gout arthritis; Pain; Inflammation; NF kappa B; Inflammasome
资金
- Coordenadoria de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Financiadora de Estudo e Projetos-Apoio a Infraestrutura (CT-INFRA 01/2011) [01.13.0049.00]
- Sao Paulo Research Foundation (FAPESP) [2011/19670-0, 2010/15014-9, 2013/08216-2]
- Center for Research on Inflammatory Diseases (GRID)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Ministerio da Ciencia, Tecnologia e Inovacao (MCTI)
- Secretaria da Ciencia, Tecnologia e Ensino Superior (SETI)
- Decit/SCTIE/MS through CNPq
- Fundacao Araucaria and Secretaria da Saude do Estado do Parana (SESA-PR)
- Parana State Government (Brazil)
- CNPq
- CAPES
The effects and mechanisms of the citrus flavonoid naringenin were investigated in a mouse model of gout arthritis induced by intra-articular injection of monosodium urate crystals (MSU). Mice were treated with naringenin (16.7-150 mg/kg, per oral) 1 h before MSU (100 mu g/kg, i.a.) stimulus. MSU induced joint pain and edema, which were inhibited by naringenin at the dose of 150 mg/kg, without inducing liver and kidney toxicity. Naringenin inhibited MSU-induced histopathological changes, leukocyte recruitment, cytokine production, oxidative stress, NF kappa B activation, NLRP3 inflammasome components mRNA expression, and IL-1 beta maturation in cultured macrophages. The present data support the therapeutic applicability of naringenin in the treatment of gout arthritis.
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