期刊
JOURNAL OF FUNCTIONAL FOODS
卷 46, 期 -, 页码 268-277出版社
ELSEVIER
DOI: 10.1016/j.jff.2018.05.003
关键词
Green tea polyphenols; Obesity; Modulatory effect; Intestinal microbiota; Metagenomics
资金
- National Natural Science Foundation of China [31501473]
- Key Research and Development Project of Zhejiang Province [2017C02039, 2018C02047]
- People-benefit Project of Ningbo [2015C10061]
- K.C. Wong Magna Fund in Ningbo University
This study focused on the modulatory effect of green tea polyphenols (GTP) on human intestinal microbiota, and its underlying anti-obesity mechanisms. GTP was prepared from Chinese green tea by column chromatography, and then the influence of GTP on intestinal microbiome was analyzed with a human flora-associated (HFA) high fat diet-induced obesity mice model by metagenomics. GTP ameliorated the obesity-induced gut dysbiosis; in addition, a significant decrease was observed in Firmicutes/Bacteroidetes after GTP treatment. Moreover, KEGG pathways of ATP-binding cassette (ABC) transporters, two-component system and biosynthesis of amino acids enriched the most differentially expressed genes after GTP intervention for 8 weeks. Our results may have important implications for the use of GTP as a functional food component with potential therapeutic utility against high fat diet induced obesity, and prebiotic-like activity by modulating intestinal microbiota and affecting certain metabolic pathways, contributing to the improvement of host health.
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