期刊
JOURNAL OF FUNCTIONAL FOODS
卷 46, 期 -, 页码 136-146出版社
ELSEVIER
DOI: 10.1016/j.jff.2018.04.061
关键词
Dendropanax morbifera; Type 2 diabetes mellitus; Retinal degeneration; Db/db mice; Glucose transporter; AMP-activated protein kinase
资金
- Ministry of Trade, Industry, and Energy (MOTIE), Korea, under the Regional Specialized Industry Development Program [R0004742]
- Ministry of Trade, Industry & Energy (MOTIE), Republic of Korea [R0004742] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
To appraise the effects and involved mechanism of Dendropanax morbifera leaves extract (DLE) on diabetes and retinal degeneration, in this study, male C57BLKS/J-m+/db and five groups of db/db mice were treated with 0.5% CMC or metformin or three doses of DLE for 6 weeks. Administration of DLE stimulated AMP-activated protein kinase in the liver, skeletal muscle and adipose tissue, leading to the improvement of gene and protein expression related with insulin resistance and glucose homeostasis in db/db mice. Morphological changes and insulin depletion of pancreatic islets were also attenuated by treatment of DLE. Moreover, DLE treatment prevented the deterioration of retina by regulating not only the gene expression related with apoptosis and neovascularization, but also the level of activator protein-1 in retina. Therefore, DLE improves diabetic phenotype and retinal degeneration, suggesting that IDLE could be a prospective agent for preventing diabetes and related eye complication.
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