期刊
JOURNAL OF FUNCTIONAL FOODS
卷 45, 期 -, 页码 321-329出版社
ELSEVIER
DOI: 10.1016/j.jff.2018.03.039
关键词
Obesity; High-fat diet; Probiotic; Macrophage; Adipocyte; Cytokine
资金
- Granarolo S.p.A, project MIAOver-50 Nutrizione, salute e qualita della vita: sviluppo di nuove formulazioni e ricettazioni dei prodotti tradizionali della dieta Made in Italy, ottimizzate per i consumatori over-50
We investigated the efficacy of different probiotics and bacteria used in dairy products to prevent the development of obesity and ameliorate established obesity in C57BL/6J mice fed a high fat diet (HFD). For the preventive efficacy, Lactobacillus rhamnosus GG, L. acidophilus LA1/K8, a mixture of Bifidobacterium lactis Bi1, B. breve Bbr8 and B. breve BL10 (B. mix), or a mixture of L. bulgaricus Lb2 and S. termophilus Z57 were given to mice before (2 weeks) and together with HFD (12 weeks). B. mix was selected for its anti-obesity activity and assessed in established obesity by feeding mice the HFD for 24 weeks and B. mix for the last 12 weeks. We found that B. mix was able to both prevent and ameliorate established obesity by reducing weight gain, adipose tissue fat accumulation, adipocyte size, and macrophage and CD4(+) T cell infiltration, improving lipid profile and regulating leptin and cytokine secretion.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据