期刊
JOURNAL OF FUNCTIONAL FOODS
卷 45, 期 -, 页码 371-380出版社
ELSEVIER
DOI: 10.1016/j.jff.2018.04.025
关键词
Medicago sativa L.; Isoflavane glycosides; Antioxidant activity; AChE inhibitory activity; Neuroprotective activity
资金
- key R&D and technology transfer program [Y17-0-001]
- National Natural science Foundation of China [81703378]
- Foundation from the Project of Education Department of Liaoning province of P. R. China [LQ2017016, L2016009]
- Foundation from the Project of Science and Technology Department of Liaoning province of P. R. China [20170023, 20170520250, 20170540723]
- Super computing Environment of the Chinese Academy of Sciences (China ScGrid)
Medicago saliva L. is an important source of functional foods and supplements, which can improve human health. The present work was carried out to search for potential antioxidants from M. saliva to treat neurodegeneration. Four new isoflavane glycosides (1-4) were isolated from M. saliva, along with seven known compounds (5-11). Their structures including absolute configurations were elucidated by multi-spectroscopic data analyses, chemical methods, and quantum chemical ECD calculations. The compounds (1-11) were tested for their antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonicacid) (ABTS) and Ferric reducing antioxidant power (FRAP) assays. All the isolated compounds displayed different degrees of antioxidant effects. Meanwhile, some isolates also possessed acetylcholinesterase (AChE) inhibitory activities. A possible mechanism of interaction between the active compounds and AChE was also investigated by molecular docking studies. Furthermore, compounds (1-6 and 10-11) exhibited potent neuroprotective effects against H2O2-induced cellular damage in human neuroblastoma SH-SY5Y cells.
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