期刊
JOURNAL OF FUNCTIONAL FOODS
卷 40, 期 -, 页码 573-581出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2017.11.045
关键词
Proanthocyanidins; Chinese bayberry leaves; Ovarian cancer; Angiogenesis; Cell cycle; Akt
资金
- NIH from the National Center for Research Resources [P20RR016477]
- National Institute for General Medical Sciences (NIGMS) [P20GM103434]
- NIGMS, a component of the National Institutes of Health (NIH) [P20GM104932]
- COBRE [GM102488/RR032138]
- ARIA S10 grant [RR020866]
- FORTESSA S10 grant [OD016165]
- INBRE [GM103434]
- National Natural Science Foundation of China [C200501]
- National Key Research and Development Program [2016YFD0400805]
Ovarian cancer is the leading cause of death from gynecological malignancy and natural products have drawn great attention for cancer treatment. Chinese bayberry leaves proanthocyanidin (BLPs) with epigallocatechin-3-gallate (EGCG) as its terminal and major extension units is unusual in the plant kingdom. In the present study, BLPs showed strong growth inhibitory effects on cisplatin-resistant A2780/CP70 cells by inhibiting angiogenesis and inducing G1 cell cycle arrest. BLPs reduced the tube formation in HUVECs and attenuated the wound healing ability in A2780/CP70 cells. BLPs further reduced the level of ROS and targeted Akt/mTOR/p70S6K/4E-BP-1 pathway to reduce the expression of HIF-1 a and VEGF, and thus inhibited angiogenesis. Furthermore, BLPs induced G1 cell cycle arrest by reducing the expressions of c-Myc, cyclin Dl and CDK4, which was also in accordance with the flow cytometry analysis. Overall, these results indicated that BLPs could be a valuable resource of natural compounds for cancer treatment.
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