期刊
ONCOTARGETS AND THERAPY
卷 11, 期 -, 页码 3817-3826出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S168317
关键词
macrophage; cancer stem cell; tumor immunology; inflammatory cytokine; tumor microenvironment
资金
- National Natural Science Foundation of China [81774261, 81373582]
- Natural Science Foundation of Guangdong Province [S2013010012636]
- Administration of Traditional Chinese Medicine of Guangdong [20171001, 20181008, 20181002]
- Foundation of GuangZhou Science Technology and Innovation Commission [201803010088, 201804010118]
Cancer stem cells are a small population of cells with the potential for self-renewal and multi-directional differentiation and are an important source of cancer initiation, treatment resistance, and recurrence. Epithelial-mesenchymal transition (EMT)is a process in which epithelial cells lose their epithelial phenotype and convert to mesenchymal cells. Recent studies have shown that cancer cells undergoing EMT can become stem-like cells. Many kinds of tumors are associated with chronic inflammation, which plays a role in tumor progression. Among the various immune cells mediating chronic inflammation, macrophages account for similar to 30%-50% of the tumor mass. Macrophages are highly infiltrative in the tumor microenvironment and secrete a series of inflammatory factors and cytokines, such as transforming growth factor (TGF)-beta, IL-6, IL-10, and tumor necrosis factor (TNF)-alpha, which promote EMT and enhance the stemness of cancer cells. This review summarizes and discusses recent research findings on some specific mechanisms of tumor-associated macrophage-derived cytokines in EMT and cancer stemness transition, which are emerging targets of cancer treatment.
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