期刊
BIOANALYSIS
卷 10, 期 7, 页码 489-516出版社
FUTURE SCI LTD
DOI: 10.4155/bio-2017-0285
关键词
amino acids; LC-MS/MS; lipids; neurotransmitters; quantitation; steroids; targeted metabolomics; untargeted metabolomics; urine
资金
- EU's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant [712949]
- Agency for Business Competitiveness of the Government of Catalonia
- Spanish Health National System [CPII16/00027]
Urine is a biologicalmatrix that contains hundreds of metabolic end products which constitute the urinary metabolome. The development and advances on LC-MS/MS have revolutionized the analytical study of biomolecules by enabling their accurate identification and quantification in an unprecedented manner. Nowadays, LC-MS/MS is helping to unveil the complexity of urine metabolome, and the results obtained have multiple biomedical applications. This review focuses on the targeted LC-MS/MS analysis of the urine metabolome. In the first part, we describe general considerations (from sample collection to quantitation) required for a proper targeted metabolic analysis. In the second part, we address the urinary analysis and recent applications of four relevant families: amino acids, catecholamines, lipids and steroids.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据