Synthesis of 4-aryl-2-thioxo-3,4-dihydropyrimidines using a three-component reaction of Meldrum's acid with arylaldehydes and acetylthiourea

A one-pot method for the preparation of new 4-aryl-2-thioxo-3,4-dihydropyrimidines via a three-component reaction of Meldrum's acid with arylaldehydes and acetylthiourea in the presence of p-toluenesulfonic acid as catalyst in CH3CN under reflux is reported.