期刊
CHEMICAL SCIENCE
卷 9, 期 11, 页码 3014-3022出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7sc05040b
关键词
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资金
- Max-Planck-Gesellschaft
- Boehringer Ingelheim Fonds
- Alexander von Humboldt Foundation
- European Research Council (ChemBioAP)
- Behrens-WeiseStiftung
- Grants-in-Aid for Scientific Research [17K01970] Funding Source: KAKEN
Macroautophagy is a conserved eukaryotic process for degradation of cellular components in response to lack of nutrients. It is involved in the development of diseases, notably cancer and neurological disorders including Parkinson's disease. Small molecule autophagy modulators have proven to be valuable tools to dissect and interrogate this crucial metabolic pathway and are in high demand. Phenotypic screening for autophagy inhibitors led to the discovery of the novel autophagy inhibitor aumitin. Target identification and confirmation revealed that aumitin inhibits mitochondrial respiration by targeting complex I. We show that inhibition of autophagy by impairment of mitochondrial respiration is general for several mitochondrial inhibitors that target different mitochondrial complexes. Our findings highlight the importance of mitochondrial respiration for autophagy regulation.
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