期刊
CHEMICAL SCIENCE
卷 9, 期 15, 页码 3685-3693出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7sc04963c
关键词
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资金
- National Basic Research Program of China (973 Program) [2013CB834701, 2013CB834702]
- University Grants Committee of Hong Kong [AoE/P-03/08]
- Research Grants Council of Hong Kong [16301614, 16305015, N_HKUST604/14]
- Innovation and Technology Commission [ITC-CNERC14SC01]
- National Natural Science Foundation of China [81372274, 81501591, 8141101080]
- Science and Technology Planning Project of Guangdong Province [2014A030313033, 2014A050503037]
- Shenzhen Science and Technology Program [JCYJ20130402103240486, JCYJ20160509170535223]
- Guangdong Innovative Research Team Program of China [201101C0105067115]
- Hong Kong Scholars Program [XJ2016008]
The synthesis of water-soluble near-infrared (NIR)-emissive fluorescent molecules with aggregation-induced emission (AIE) characteristics and theranostic functions is highly desirable but remains challenging. In this work, we designed and readily prepared for the first time such a molecule with AIE features, good water-solubility and intense emission in the NIR region. This AIE luminogen (AIEgen) is able to specifically light up the cell membrane without the involvement of a washing procedure. Interestingly, the staining process can be performed by simply shaking the culture with cells at room temperature for only a few seconds after the addition of the AIEgen, indicating an ultrafast and easy-to-operate staining protocol. This is the first fluorescent light-up probe for cell-imaging that allows the combination of a short staining period (at the second-level) with a wash-free process. Additionally, the presented AIEgen has also been developed to serve as an excellent phototherapeutic agent for high efficiency generation of reactive oxygen species (ROS) upon visible light irradiation, which allows its effective application in the photodynamic ablation of cancer cells, demonstrating its dual role as an imaging and phototherapeutic agent.
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