期刊
CHEMICAL SCIENCE
卷 9, 期 8, 页码 2087-2091出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7sc04989g
关键词
-
资金
- Fundamental Research Funds for the Central Universities
- Program of Tianjin Young Talents
- NSFC [21672112]
We designed a water-soluble guanidinium-modified calix[5]arene to target lysophosphatidic acid (LPA), an ideal biomarker for early diagnosis of ovarian and other gynecologic cancers, achieving binding on the nanomolar level. An indicator displacement assay, coupled with differential sensing, enabled ultrasensitive and specific detection of LPA. Moreover, we show that using a calibration line, the LPA concentration in untreated serum can be quantified in the biologically relevant low mu M range with a detection limit of 1.7 mu M. The reported approach is feasible for diagnosing ovarian and other gynecologic cancers, particularly at their early stages.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据