期刊
CHEMICAL SCIENCE
卷 9, 期 25, 页码 5630-5639出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8sc01288a
关键词
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资金
- National Natural Science Foundation of China (NSFC)
- 973 Program [2014CB932103]
- Beijing Natural Science Foundation [2174082]
- Fundamental Research Funds for the Central Universities [buctylkxj01]
Recently, ultrathin two-dimensional (2D) nanomaterials have attracted considerable research interest in biomedical applications, owing to their intriguing quantum size and surface effects. In this work, a onestep bottom-up method is developed to prepare rare-earth (Gd3+ and Yb3+) co-doped layered double hydroxide (LDH) monolayer nanosheets, with a precisely controlled composition and uniform morphology. Due to the successful introduction of Gd3+ and Yb3+ into the LDH host layer, the Gd& YbLDH monolayer nanosheets exhibit excellent magnetic resonance (MR)/X-ray computed tomography (CT) dual-mode imaging functionality. Moreover, the Gd& Yb-LDH monolayer nanosheets achieve an ultrahigh loading of a chemotherapeutic drug (SN38) with a loading content (LC) of 925%, which is a one order of magnitude enhancement compared with previously reported delivery systems of hydrophobic drugs. Interestingly, by further combination with indocyanine green (ICG), in vivo tri-mode imaging, including CT, MR and near infrared fluorescence (NIRF) imaging, is achieved, which enables a noninvasive visualization of cancer cell distribution with deep spatial resolution and high sensitivity. In addition, in vitro and in vivo therapeutic evaluations demonstrate an extremely high tri-mode synergetic anticancer activity and superior biocompatibility of SN38& ICG/Gd& Yb-LDH. Therefore, this work demonstrates a paradigm for the synthesis of novel multifunctional 2D monolayer materials via a facile bottom-up route, which shows promising applications in cancer synergetic theranostics.
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