期刊
CHEMICAL SCIENCE
卷 9, 期 12, 页码 3105-3110出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8sc00206a
关键词
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资金
- Office of Science (BER), U.S. Department of Energy [DE-SC0008397]
- International Cooperative Program of the Chinese Academy of Sciences [GJHZ1622]
- National Basic Research Program of China [2012CB933301]
- National Natural Science Foundation of China [21674048, 21574064, 81572163, 61378081]
- Synergetic Innovation Center for Organic Electronics and Information Displays
- Natural Science Foundation of Jiangsu Province of China [NY211003]
- Huanghe Talents Project of Wuhan City
A diketopyrrolopyrrole-based semiconducting polymer nanoparticle (PDFT1032) has been developed as a NIR-II (near infrared window II, 1000-1700 nm) fluorescent probe. It shows high photostability, a favorable absorption peak at 809 nm, a large Stokes shift of 223 nm, outstanding biocompatibility and minimal in vivo toxicity. More importantly, the versatile use of PDFT1032 for several important biomedical applications in the NIR-II window has been demonstrated, including the NIR-II optical imaging of tumors on a subcutaneous osteosarcoma model, assessing the vascular embolization therapy of tumors, and NIR-II image-guided orthotopic tumor surgery and sentinel lymph node biopsy (SLNB) with high spatial and temporal resolution. Overall, excellent biocompatibility, favorable hydrophilicity, and desirable chemical and optical properties make the semiconducting polymer nanoparticle PDFT1032 a highly promising NIR-II imaging probe with the potential to be widely applicable in clinical imaging and the surgical treatment of malignancy.
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