期刊
CHEMICAL SCIENCE
卷 9, 期 23, 页码 5191-5196出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8sc01486h
关键词
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资金
- European Research Council (ERC Starting Grant) [306793 - CASAA]
- Sumitomo Dainippon
We report the facile formation of trifluoroborate-iminiums (TIMs) from potassium acyltrifluoroborates (KATs) and the transformation of TIMs to a-aminotrifluoroborates by reduction or Grignard additions. Conditions for the hydrolysis of a-aminotrifluoroborates to a-aminoboronic acids, which are important biologically active compounds, were established. This new methodology allows access to sterically demanding a-aminoboronic acids that are not easily prepared with currently available methods. This work also introduces TIMs, that can be easily prepared and handled, as a new category of functional groups that serve as precursors to valuable organic compounds.
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