期刊
CHEMICAL SCIENCE
卷 9, 期 8, 页码 2348-2356出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7sc05059c
关键词
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资金
- Royal Society
- Leverhulme Trust [RPG-2015-248]
- ERC [FluoroFix: 677367]
Through a combined experimental and computational (DFT) approach, the reaction mechanism of the addition of fluoroarenes to Mg-Mg bonds has been determined as a concerted SNAr-like pathway in which one Mg centre acts as a nucleophile and the other an electrophile. The experimentally determined Gibbs activation energy for the addition of C6F6 to a Mg-Mg bond of a molecular complex, Delta G(298) (K)(experiment) = 21.3 kcal mol(-1) is modelled by DFT with the omega B97X functional, Delta G(298) (K)(DFT) = 25.7 kcal mol(-1). The transition state for C-F activation involves a polarisation of the Mg-Mg bond and significant negative charge localisation on the fluoroarene moiety. This transition state is augmented by stabilising closed-shell Mg center dot center dot center dot F-ortho interactions that, in combination with the known trends in C-F and C-M bond strengths in fluoroarenes, provide an explanation for the experimentally determined preference for C-F bond activation to occur at sites flanked by ortho-fluorine atoms. The effect of modification of both the ligand coordination sphere and the nature and polarity of the M-M bond (M = Mg, Zn, Al) on C-F activation has been investigated. A series of highly novel beta-diketiminate stabilised complexes containing Zn-Mg, Zn-Zn-Zn, Zn-Al and Mg-Al bonds has been prepared, including the first crystallographic characterisation of a Mg-Al bond. Reactions of these new M-M containing complexes with perfluoroarenes were conducted and modelled by DFT. C-F bond activation is dictated by the steric accessibility, and not the polarity, of the M-M bond. The more open coordination complexes lead to enhanced Mg center dot center dot center dot F-ortho interactions which in turn lower the energy of the transition states for C-F bond activation.
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