期刊
ANALYTICAL CELLULAR PATHOLOGY
卷 2018, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2018/2678924
关键词
-
资金
- Romanian National Authority for Scientific Research and Innovation, CNCS/CCCDI-UEFISCDI within PNCDI III [PN III-P2-2.1.BG-2016-0126, BG-15]
The present study aimed to investigate the phytochemical composition of Mentha x piperita L. (MP) and Lavandula angustifolia Mill. (LA) extracts in terms of hydroxycinnamic acid (HCAs) content, in particular, caffeic (CA), p-cumaric (CU), ferulic (FE), and rosmarinic (RS) acids using LC- MS. Also, the in vitro antimicrobial effect against Staphylococcus aureus and the antiproliferative activity against two cancerous cell lines (A375 and MDA-MB-231) using the MTT assay were tested. The extracts were prepared using aromatic water which resulted from the extraction of oils from plants as extraction medium, with/without acid. The results showed that RS and FE represent the majority of HCAs compounds; the highest content of FE is found in LA (7.47 mg.g(-1)d.m.), and the maximum content of RS in MP (6.36 mg.g(-1)d.m.). Regarding the antimicrobial effect against Staphylococcus aureus, the two extracts showed a simulative role on the growth rate of Staphyloccocus aureus, but a slightly inhibitory effect (69.12%) can be attributed to the acidic environment. In terms of biological activity against MDA-MB-231 breast carcinoma cell line, and A375 human melanoma cell line, at the highest employed concentration, 150 mu g.mL(-1), the tested extracts present a weak antiproliferative effect.
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